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[Potatojunkie]

Originally Posted by LesMTS

I'm not sure. I have a great big pharmacology text book somewhere which is great for this kind of thing, I looked briefly for it and I can't see it amongst my books and I can't be arsed looking for it.

Looks like it is paracetamol:

Chronic alcohol ingestion activates enzymes that transform acetaminophen (Tylenol and others) into chemicals that can cause liver damage, even when acetaminophen is used in standard therapeutic amounts (32,33). These effects may occur with as little as 2.6 grams of acetaminophen in persons consuming widely varying amounts of alcohol (34).

Cytochrome P450 2E1 is involved, apparently. Fucked if I know.

(32) Seeff, L.B.; Cuccherini, B.A.; Zimmerman, H.J.; Adler, E.; & Benjamin, S.B. Acetaminophen hepatotoxicity in alcoholics: A therapeutic misadventure. Annals of Internal Medicine 104(3):399-404, 1986. (33) Girre, C.; Hispard, E.; Palombo, S.; N'Guyen, C.; & Dally, S. Increased metabolism of acetaminophen in chronically alcoholic patients. Alcoholism: Clinical and Experimental Research 17(1):170-173, 1993. (34) Black, M. Acetaminophen hepatotoxicity. Annual Review of Medicine 35:577-593, 1984.