Default Sidebar

[LesMTS]

Originally Posted by Potatojunkie

Looks like it is paracetamol:



Cytochrome P450 2E1 is involved, apparently. Fucked if I know.

(32) Seeff, L.B.; Cuccherini, B.A.; Zimmerman, H.J.; Adler, E.; & Benjamin, S.B. Acetaminophen hepatotoxicity in alcoholics: A therapeutic misadventure. Annals of Internal Medicine 104(3):399-404, 1986. (33) Girre, C.; Hispard, E.; Palombo, S.; N'Guyen, C.; & Dally, S. Increased metabolism of acetaminophen in chronically alcoholic patients. Alcoholism: Clinical and Experimental Research 17(1):170-173, 1993. (34) Black, M. Acetaminophen hepatotoxicity. Annual Review of Medicine 35:577-593, 1984.

Cytochrome P450 is responsible for a whole lot of shit. It's supposed to help us out but it's a bit of a cunt of a friend. It produces shitloads of reactive oxygen species which cause DNA damage and widespread biomolecule damage leading to cancer and other shit, then there's this which you've pointed out.