i'm not quite sure what you mean by that.
it syncs with iTunes perfectly; all your iTunes songs / playlists appear in serato... and it plays either MP3s or AACs (as long as they're not protected).
You can set five cue points and nine loops per track which are stored as tags in the files themselves, so for example if there's a song that you always skip the first minute of, set a cue point there and that's where it'll start playing from...
one good (and cheap) solution might be to spend £17 on a USB
Griffin iMic thingy, which gives you a second audio output, and use serato through your headphone socket and iTunes through the USB iMic thing.
the best solution for any form of DJing involving a laptop is to buy the serato hardware box, which then gives you two virtual decks on your laptop and the ability to control them with several kinds of external hardware, but even just with the laptop it's
phenomenal.
but yeah, even without it's great for organising and cueing tracks...