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22nd June 2007, 6:43pm
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#1 | | Caissa's DeathAngel
Join Date: Dec 2004 Location: Beneath a blade
Posts: 17,009
| Paracetemol and alcohol
How long should you leave between taking paracetemol and drinking? Got a bad cold, which I'm attempting to blitz with paracetemol and large (2 litres a day) quantities of orange juice. It's the subcrawl tomorrow so of course I'll be drinking from about 1, so what's the latest time I can safely take anything? *I haven'd had one since half 6 this morning so if it's already too late that's no biggy*.
__________________ The songwriter is dead. The blade fell upon him, taking him to the White Lands of Empathica, of Innocence...
Quote:
Originally Posted by McLeary  you've just been out-hetero'd by Addy | | 
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22nd June 2007, 6:46pm
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#2 | | A Jubilant Mass Editor
Join Date: Feb 2003 Location: In a jar, mate.
Posts: 17,266
| Re: Paracetemol and alcohol
Four hours.
I can't back this up if challenged.
Or zero minutes, providing you've a reasonably healthy liver.
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22nd June 2007, 6:48pm
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#3 | | Fattly Drawn Boy Editor
SuperMod
Join Date: Sep 2004 Location: Dundee
Posts: 16,770
| Re: Paracetemol and alcohol
Couple of hours.
The only problem, I think, is that your liver has to clear out both the paracetomol and the alcohol. I don't think they interact dangerously.
So, off the top of my head, without consulting any other sources, I'd say it's actually unlikely to cause any problems but it might, so that's why they advise against it.
__________________ If Schrodinger had a cat, it would definitely be dead by now. | 
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22nd June 2007, 6:48pm
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#4 | | Caissa's DeathAngel
Join Date: Dec 2004 Location: Beneath a blade
Posts: 17,009
| Re: Paracetemol and alcohol
Aye, 4 hours seems sensible as that's the time between tablets, but I suspect it may well require longer. Last thing I want is bad side effects 
__________________ The songwriter is dead. The blade fell upon him, taking him to the White Lands of Empathica, of Innocence...
Quote:
Originally Posted by McLeary you've just been out-hetero'd by Addy | | |
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22nd June 2007, 6:50pm
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#5 | | A Jubilant Mass Editor
Join Date: Feb 2003 Location: In a jar, mate.
Posts: 17,266
| Re: Paracetemol and alcohol
Quote:
Originally Posted by LesMTS I don't think they interact dangerously. | What is it that does? I know there's some common medication that can produce worse toxins in your innards.
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22nd June 2007, 6:51pm
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#6 | | Fattly Drawn Boy Editor
SuperMod
Join Date: Sep 2004 Location: Dundee
Posts: 16,770
| Re: Paracetemol and alcohol
Quote:
Originally Posted by Addy Aye, 4 hours seems sensible as that's the time between tablets, but I suspect it may well require longer. Last thing I want is bad side effects | Whatever it says on the pack for how long to leave between doses will be the average amount of time to clear the drug from someone's system, plus some.
__________________ If Schrodinger had a cat, it would definitely be dead by now. | |
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22nd June 2007, 6:53pm
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#7 | | Y'wid tho...
Join Date: Oct 2004 Location: The Goblin City
Posts: 6,071
| Re: Paracetemol and alcohol
Go on Addy, live dangerously! 
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22nd June 2007, 6:54pm
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#8 | | Fattly Drawn Boy Editor
SuperMod
Join Date: Sep 2004 Location: Dundee
Posts: 16,770
| Re: Paracetemol and alcohol
Quote:
Originally Posted by Potatojunkie What is it that does? I know there's some common medication that can produce worse toxins in your innards. | I'm not sure. I have a great big pharmacology text book somewhere which is great for this kind of thing, I looked briefly for it and I can't see it amongst my books and I can't be arsed looking for it.
__________________ If Schrodinger had a cat, it would definitely be dead by now. | |
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22nd June 2007, 6:54pm
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#9 | | Caissa's DeathAngel
Join Date: Dec 2004 Location: Beneath a blade
Posts: 17,009
| Re: Paracetemol and alcohol
If I'm drinking as much as I did on the last subcrawl - without making dodgy phone calls - that's dangerous enough
__________________ The songwriter is dead. The blade fell upon him, taking him to the White Lands of Empathica, of Innocence...
Quote:
Originally Posted by McLeary you've just been out-hetero'd by Addy | | |
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22nd June 2007, 6:55pm
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#10 | | hypermediaocrity
Join Date: Jul 2001 Location: in white rooms
Posts: 19,984
| Re: Paracetemol and alcohol
mash the paracetamol up and pop it into your voddy coke, does wonders! | |
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22nd June 2007, 6:56pm
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#11 | | Caissa's DeathAngel
Join Date: Dec 2004 Location: Beneath a blade
Posts: 17,009
| Re: Paracetemol and alcohol
Baileys 
Or orange juice and morgans actually, if I'm feeling adventurous and still health concious
__________________ The songwriter is dead. The blade fell upon him, taking him to the White Lands of Empathica, of Innocence...
Quote:
Originally Posted by McLeary you've just been out-hetero'd by Addy | | |
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22nd June 2007, 6:57pm
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#12 | | Y'wid tho...
Join Date: Oct 2004 Location: The Goblin City
Posts: 6,071
| Re: Paracetemol and alcohol
Quote:
Originally Posted by Addy
Or orange juice and morgans actually, if I'm feeling adventurous and still health concious | That sounds vile! 
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A million lies to sell yourself is all you ever had | |
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22nd June 2007, 6:57pm
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#13 | | A Jubilant Mass Editor
Join Date: Feb 2003 Location: In a jar, mate.
Posts: 17,266
| Re: Paracetemol and alcohol
Quote:
Originally Posted by LesMTS I'm not sure. I have a great big pharmacology text book somewhere which is great for this kind of thing, I looked briefly for it and I can't see it amongst my books and I can't be arsed looking for it. | Looks like it is paracetamol: Quote: |
Chronic alcohol ingestion activates enzymes that transform acetaminophen (Tylenol and others) into chemicals that can cause liver damage, even when acetaminophen is used in standard therapeutic amounts (32,33). These effects may occur with as little as 2.6 grams of acetaminophen in persons consuming widely varying amounts of alcohol (34).
| Cytochrome P450 2E1 is involved, apparently. Fucked if I know. (32) Seeff, L.B.; Cuccherini, B.A.; Zimmerman, H.J.; Adler, E.; & Benjamin, S.B. Acetaminophen hepatotoxicity in alcoholics: A therapeutic misadventure. Annals of Internal Medicine 104(3):399-404, 1986. (33) Girre, C.; Hispard, E.; Palombo, S.; N'Guyen, C.; & Dally, S. Increased metabolism of acetaminophen in chronically alcoholic patients. Alcoholism: Clinical and Experimental Research 17(1):170-173, 1993. (34) Black, M. Acetaminophen hepatotoxicity. Annual Review of Medicine 35:577-593, 1984.
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22nd June 2007, 7:02pm
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#14 | | Fattly Drawn Boy Editor
SuperMod
Join Date: Sep 2004 Location: Dundee
Posts: 16,770
| Re: Paracetemol and alcohol
Quote:
Originally Posted by Potatojunkie Looks like it is paracetamol:
Cytochrome P450 2E1 is involved, apparently. Fucked if I know.
(32) Seeff, L.B.; Cuccherini, B.A.; Zimmerman, H.J.; Adler, E.; & Benjamin, S.B. Acetaminophen hepatotoxicity in alcoholics: A therapeutic misadventure. Annals of Internal Medicine 104(3):399-404, 1986. (33) Girre, C.; Hispard, E.; Palombo, S.; N'Guyen, C.; & Dally, S. Increased metabolism of acetaminophen in chronically alcoholic patients. Alcoholism: Clinical and Experimental Research 17(1):170-173, 1993. (34) Black, M. Acetaminophen hepatotoxicity. Annual Review of Medicine 35:577-593, 1984. | Cytochrome P450 is responsible for a whole lot of shit. It's supposed to help us out but it's a bit of a cunt of a friend. It produces shitloads of reactive oxygen species which cause DNA damage and widespread biomolecule damage leading to cancer and other shit, then there's this which you've pointed out.
__________________ If Schrodinger had a cat, it would definitely be dead by now. | |
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22nd June 2007, 7:03pm
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#15 | | Caissa's DeathAngel
Join Date: Dec 2004 Location: Beneath a blade
Posts: 17,009
| Re: Paracetemol and alcohol
Riiiight. So does this affect the length of time I need to wait?
__________________ The songwriter is dead. The blade fell upon him, taking him to the White Lands of Empathica, of Innocence...
Quote:
Originally Posted by McLeary you've just been out-hetero'd by Addy | | |
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